DBS for Treatment-Refractory Obsessive Compulsive Disorder
DBS for Treatment-Refractory Obsessive Compulsive Disorder
For this purpose, we examined original published reports on studies about DBS for OCD. A PubMed search, last update 24th of June 2013, was conducted using the terms "deep brain stimulation" and "obsessive compulsive disorder". The PubMed search resulted in 279 articles (Figure 1). We scanned all abstracts that were available in either English or German language, and included those that were peer-reviewed, published, original articles on clinical trials of DBS for OCD. In addition we used a previously published review and screened the lists of references of the relevant publications to complete our list of studies. To ensure correct data collection one researcher extracted the data and a second researcher independently checked the data extraction forms for accuracy and completeness. Finally, we included 25 articles in the present review. We summarized twenty-three articles that included information on Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) scores in five tables arranged by target structure and calculated mean response rate and mean change in Y-BOCS score for each target location. To avoid biased results we ensured to not include duplicates. For that reason not all Y-BOCS score in the tables have been included in the quantitative analysis. All studies included in this review have been approved by the responsible local ethical commission. For the purpose of reviewing published literature no ethical approval is required by the guidelines of the ethics committee of the Medical Faculty of the University of Cologne. A review protocol is not available.
(Enlarge Image)
Figure 1.
PRISMA flowchart. Process of literature search (Flowchart taken from Moher, [21]).
Methods
For this purpose, we examined original published reports on studies about DBS for OCD. A PubMed search, last update 24th of June 2013, was conducted using the terms "deep brain stimulation" and "obsessive compulsive disorder". The PubMed search resulted in 279 articles (Figure 1). We scanned all abstracts that were available in either English or German language, and included those that were peer-reviewed, published, original articles on clinical trials of DBS for OCD. In addition we used a previously published review and screened the lists of references of the relevant publications to complete our list of studies. To ensure correct data collection one researcher extracted the data and a second researcher independently checked the data extraction forms for accuracy and completeness. Finally, we included 25 articles in the present review. We summarized twenty-three articles that included information on Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) scores in five tables arranged by target structure and calculated mean response rate and mean change in Y-BOCS score for each target location. To avoid biased results we ensured to not include duplicates. For that reason not all Y-BOCS score in the tables have been included in the quantitative analysis. All studies included in this review have been approved by the responsible local ethical commission. For the purpose of reviewing published literature no ethical approval is required by the guidelines of the ethics committee of the Medical Faculty of the University of Cologne. A review protocol is not available.
(Enlarge Image)
Figure 1.
PRISMA flowchart. Process of literature search (Flowchart taken from Moher, [21]).
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