Fecal Microbiota Transplant in Children With and Without IBD
Fecal Microbiota Transplant in Children With and Without IBD
Faecal microbiota transplantation gives sustained eradication of C. difficile in children with and without IBD. There is increased bacterial diversity in patients after FMT. However, by 6 months post-FMT, those with IBD have decreased bacterial diversity compared with donors, whereas those without IBD have diversity similar to donors. This suggests that FMT-restored faecal diversity is sustained in children without IBD, but not in IBD patients. This may provide insight into why IBD patients are susceptible to recurrent CDI.
Conclusions
Faecal microbiota transplantation gives sustained eradication of C. difficile in children with and without IBD. There is increased bacterial diversity in patients after FMT. However, by 6 months post-FMT, those with IBD have decreased bacterial diversity compared with donors, whereas those without IBD have diversity similar to donors. This suggests that FMT-restored faecal diversity is sustained in children without IBD, but not in IBD patients. This may provide insight into why IBD patients are susceptible to recurrent CDI.
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