The Iron Overload Syndromes
The Iron Overload Syndromes
Orthotropic liver transplantation (OLT) is indicated in patients with haemochromatosis who develop decompensated cirrhosis and/or HCC. Previous studies suggest post-OLT survival in patients with iron overload is poor and iron depletion prior to transplant may improve survival. One study in patients with HH reported a 1-year survival of 54% compared with 79% survival in other liver recipients. However, a recent study has suggested survival following liver transplantation due to HH has improved in recent years and may be similar to other causes of liver disease. Increased infections (especially fungal) in the first year after transplantation and cardiac complications after 1 year were the most common causes of posttransplantation deaths in HH.
Orthotropic Liver Transplantation
Orthotropic liver transplantation (OLT) is indicated in patients with haemochromatosis who develop decompensated cirrhosis and/or HCC. Previous studies suggest post-OLT survival in patients with iron overload is poor and iron depletion prior to transplant may improve survival. One study in patients with HH reported a 1-year survival of 54% compared with 79% survival in other liver recipients. However, a recent study has suggested survival following liver transplantation due to HH has improved in recent years and may be similar to other causes of liver disease. Increased infections (especially fungal) in the first year after transplantation and cardiac complications after 1 year were the most common causes of posttransplantation deaths in HH.
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