Signs and Symptoms of Exocrine Pancreatic Insufficiency

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Signs and Symptoms of Exocrine Pancreatic Insufficiency When you have exocrine pancreatic insufficiency (EPI), your body will let you know. Your pancreas doesn’t make the enzymes you need to digest food, so you won’t get enough important vitamins and nutrients from your diet. That can lead to a few classic signals of the condition.

You might feel or notice:

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  • You’re losing weight without trying. It’s a common symptom of EPI.
  • Greasy, foul-smelling stools that float or are tough to flush. It’s a sign your body isn’t absorbing fat from your diet like it should.    
  • Diarrhea.
  • Stomach cramps. You might be bloated, too.
  • Bad-smelling gas. When you don’t absorb food well, bacteria can grow in your intestine and release smelly gases.
  • Swelling in your lower legs.
  • Skin that’s pale, bruises easily, or gets rashes.

You might not have all of these symptoms, but you should let your doctor know what you’ve been feeling.

More Clues


Besides its outward symptoms, EPI also affects your body in ways you can’t always see or feel.

When you don’t absorb fat and other nutrients from food well, your body can be low on vitamins A, D, E and K. Without them, you could become less able to see at night or in low light, a condition called night blindness. You could also get bone diseases, such as osteopenia (low bone mass). EPI can also lead to anemia, in which your blood doesn’t have enough healthy red blood cells.

In severe cases, you might have bones that break easily, muscle spasms or cramps, and seizures. Not getting enough vitamins and nutrients from food due to EPI can also cause problems with walking and balance, and weakness or numbness in your hands and feet.

Gut Advice


If you have EPI, your doctor can recommend treatments that can help, along with other ways you can improve your digestion. If you’re not getting better, tell your doctor.
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